Antiviral activities of sulfated polysaccharides isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales) |
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Authors: | Bouhlal Rhimou Haslin Camille Chermann Jean-Claude Colliec-Jouault Sylvia Sinquin Corinne Simon Gaelle Cerantola Stephane Riadi Hassane Bourgougnon Nathalie |
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Institution: | Laboratoire de Biotechnologie et Chimie Marines (LBCM), Centre de Recherche Yves Coppens, Université Européenne de Bretagne (UEB), Université de Bretagne-Sud. Vannes, France. |
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Abstract: | Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 μg/mL. In addition, polysaccharides were capable of inhibiting the in vitro replication of Herpes simplex virus type 1 (HSV-1) on Vero cells values of EC50 of 4.1 and 17.2 μg/mL, respectively. The adsorption step of HSV-1 to the host cell seems to be the specific target for polysaccharide action. While for HIV-1, these results suggest a direct inhibitory effect on HIV-1 replication by controlling the appearance of the new generations of virus and potential virucidal effect. The polysaccharides from S. coronopifolius (PSC) and B. thuyoides (PBT) were composed of galactose, 3,6-anhydrogalactose, uronics acids, sulfate in ratios of 33.1, 11.0, 7.7 and 24.0% (w/w) and 25.4, 16.0, 3.2, 7.6% (w/w), respectively. |
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Keywords: | Herpes simplex virus human immunodeficiency virus antiviral activity sulfated polysaccharide S coronopifolius B thuyoides chemical composition |
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