氧氟沙星对霉形体与大肠杆菌合并感染鸡的药效学研究

以试管两倍稀释法测得氧氟沙星及其对照药物恩诺沙星、洛美沙星和强力霉素对鸡败血霉形体的最小抑菌浓度分别为０．００６２５、０．０２５、０．４和０．４ｍｇ／Ｌ。５０、１００、２００ｍｇ／Ｌ氧氟沙星、５０ｍｇ／Ｌ恩诺沙星、５０ｍｇ／Ｌ洛美沙星和１００ｍｇ／Ｌ强力霉素连续５ｄ饮水给药，对人工合并感染败血霉形体和大肠杆菌病鸡的治愈率分别是９３．３％、９６．７％、９６．７％、１００％、９６．７％和８３．３％，感

PHARMACODYNAMIC STUDIES OF OFLOXACIN IN CHICKENS INFECTED WITH MG AND E COLI

Minimal inhibitory concentrations (MICs)of ofloxacin,enrofloxacin,lomefloxacin and doxycycline against Mycoplasma galliseptican (MG) were determined by two fold diltution method in Vitro MICs of ofloxacin,enrofloxacin,lomefloxacin and doxycycline were 0 00625,0 025,0 4,0 4 mg/L,respectively The disease model was performed in 240 33 day old chickens by inoculating MG into the air sac and E coli into the breast muscle All the therapeutic groups of chickens were medicated for 5 successive days via drinking water with ofloxacin (50,100 and 200 mg/L),enrofloxacin (50mg/L),lomefloxacin (50mg/L) and doxycycline (100mg/L),respectively,the other group was unmedicated as infected control The curative rates of 50,100 and 200mg/L ofloxacin for infected chickens were 93 3%,96 7% and 96 7%,respectively The mortality of infected control group was 26 7% Ofloxacin exhibited high efficacy in controlling the infection,which was equivalent or superior to enrofloxacin,also superior to lomefloxacin and doxycycline in the curative rates,effective rates and weigh gain,in reducing mortality and frequency of MG reisolation,as well as in preventing seroconversion and air sac lecions in surviving birds