二氯菊酸光学纯度的毛细管气相色谱法测定研究

使用以 2 ,6 -二 -O-戊基 - 3-O-丁酰基 -β-环糊精作手性固定相制成的毛细管手性柱 ,用气相色谱法在 120℃成功地分离了外消旋二氯菊酸甲酯对映体 ,其中对顺、反外消旋二氯菊酸甲酯对映体的手性分离因子分别达到 1.03和 1.04 ,均大于测定光学纯度 (e.e.% )值所要求的 1.02。测定了 4种手性二氯菊酸甲酯的光学纯度 ,方法简便易行 ,可用于二氯菊酸的光学纯度测定

The Study on the Determination of the Optical Purity of Permethrinic Acid by Capillary Gas Phase Chromatography

Using 2,6-di-O-pentyl-3-O-butyryl-β-cyclodextrin as chiral stationary phase of capillary gas chromatography, four enantiomers of racemic methyl ester of permethrinic acid were baseline resolved at 120℃. The relative retention values ( α ) for the enantiomers of cis-and trans-methyl ester of permethrinic acid is 1.03 and 1.04, respectively. It is all larger than 1.02, which is the requirement for the determination of the optical purity ( e.e .%) of chiral compounds. So, the optical purity of four chiral permethrinic acid was determined successfully and conveniently.