Selection of Anopheles stephensi with DDT and dieldrin and cross-resistance spectrum to pyrethroids and fipronil |
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| Authors: | B Davari H Vatandoost MA Oshaghi AA Enayati HR Basseri AA Hanafi-Bojd |
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| Institution: | a Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Research, Tehran University of Medical Science, P.O. Box 6446, Tehran 14155, Iran
b Department of Medical Entomology, School of Public Health and Environmental Health Research Center, Sari, Iran |
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| Abstract: | The field strain of Anopheles stephensi, the main malaria vector in south of Iran, was colonized in laboratory and selected with DDT and dieldrin in two separate lines for 3 generations to a level of 19.5- and 14-fold for DDT and dieldrin resistance, respectively. Synergist tests with chlorofenethol (DMC) and piperonyl butoxide (PBO) on the selected strains indicated that dehydrochlorination and oxidative detoxification might be the underlying mechanisms involved in the resistance to dieldrin and DDT in selected strains. DDT selection decreased susceptibility to DDT and pyrethroids including lambdacyhalothrin, permethrin deltamethrin and cyfluthrin. The result also showed that selection with dieldrin caused negative and positive cross-resistance to pyrethroid and fipronil, respectively. Based on these results, it can be concluded that besides metabolic resistance mechanisms, other factors such as mutation in γ aminobutyric acid (GABA) and voltage-gated sodium channels (Kdr) might be involved. |
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| Keywords: | An stephensi Selection Cross-resistance Iran Malaria DDT Dieldin Pyrethroid |
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