新一代驱虫抗生素—莫西菌素

莫西菌素同伊维菌素一样 ,是一种目前广泛用于兽医临床的广谱、高效、新型大环内酯类驱虫抗生素 ,是美贝霉素家族中的一员。由于其独特的理化性质 ,在国外 ,已被广泛用于治疗奶牛、猪等动物体内外寄生虫病。文章对莫西菌素的理化特性、作用机制、药动学、制剂、药效、耐药性、毒性、残留等进行了较详细地综述 ,同时也介绍了减少耐药性产生的一些方法 ,为该药能在国内应用提供第一手资料 ,以求为兽医临床用药提供参考

A New Generation of Anthelminthic Antibiotic-Moxidectin

Moxidectin, a broad spectrum, high efficacy of macrocylic lactone anthelmintic, is widely used currently in the field of veterinary like Ivermectin. And it is regarded as one of the family of milbemycins.Since its particular features of physics and chemistry.The medicine has been widely to cure for the diseases of the milk cows, pigs parasites in or out of body, has the tendency to replace Ivermetin. Compared with Ivermectin,it has some differences and adventages, especially the small animals to be sensitive to Ivermectin.The paper made a review of its physics and chemistry,mode of action,pharmacokinetics,preparation,pharmacodynamics,resistance,toxicology,residue.The article may provide some informations for its application firstly and references for veterinarians at home.