中药产复康对免疫功能低下小鼠细胞因子的影响

[目的]研究产复康对免疫功能低下小鼠细胞因子的影响，为进一步研究其对机体免疫功能的影响提供基础：[方法]通过给小鼠2次皮下注射40mg/kg体重的环磷酰胺，建立免疫抑制模型，并分别以10、15、2．0g/kg的剂量灌服产复康，检测小鼠血清中细胞因子IL10、IL-2和TNFα水平的变化，[结果]单一灌服产复康明显提高了正常小鼠血清中的IL-1β、IL-2和TNFα水平；环磷酰胺降低了小鼠血清中IL-1β、IL-2和TNFQ水平；产复康显著提高免疫抑制小鼠血清中IL-1β、IL-2和TNFα水平。[结论]产复康能拮抗环磷酰胺的免疫抑制，提高机体的免疫功能。

Effects of Chanfukang(Chinese Medicine) on the Cytokine Level of Immunosuppressive Mouse

[Objective] The research aimed to study the effects of Chanfukang on the cytokines of immunosuppressive mice,providing the basis for the further research of its effects on immune function.[Method] Immunosuppressive mouse model was established through twice intraperitoneal injection with cyclophosphamide at the dose of 40 mg/kg.After the mice were gavaged respectively with Chanfukang at the dose of 10,15 and 20 g/kg,the level of cytokines(IL-1β,IL-2 and TNF α) were detected.[Result] Chanfukang significantly increased the level of IL-1β,IL-2 and TNF α in the serum of mice gavaged only with Chanfukang;the level of IL-1β,IL2 and TNF α was inhibited in mice treated with cyclophosphamide;Chanfukang significantly increased the level of IL-1β,IL-2 and TNF α in the serum of immunosuppressive mice.[Conclusion] Chanfukang should antagonize the immunosuppression of cyclophosphamide and improve the immune function.