| 减毒沙门氏菌载体构建策略研究进展 |
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| 引用本文： | 刘明荣,朱良全.减毒沙门氏菌载体构建策略研究进展[J].中国兽药杂志,2014,48(1):62-65. |
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| 作者姓名： | 刘明荣 朱良全 |
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| 作者单位： | 北京农业职业学院,中国兽医药品监察所 |
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| 基金项目： | 北京市科技新星计划(xx2013099) |
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| 摘 要： | 减毒沙门氏菌能诱导粘膜、体液及细胞免疫，不仅其自身能够产生免疫效应，而且还能携带外源基因诱导宿主特异性应答，是具有广泛应用前景的疫苗载体。本文从减毒致弱菌株构建、外源基因高效表达等方面综述了减毒沙门氏菌载体构建策略的新进展，进而对减毒沙门氏菌活载体应用中待解决的科学问题进行了归纳。
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| 关 键 词： | 减毒沙门氏菌 载体 构建策略 |
| 收稿时间： | 2013/10/29 0:00:00 |
| 修稿时间： | 2013/12/27 0:00:00 |
The progress of the vector construction of attenuated Salmonella |
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| LIU Ming-rong,ZHU Liang-quan.The progress of the vector construction of attenuated Salmonella[J].Chinese Journal of Veterinary Drug,2014,48(1):62-65. |
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| Authors: | LIU Ming-rong ZHU Liang-quan |
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| Institution: | Beijing Vocational College of Agriculture, |
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| Abstract: | Attenuated Salmonella can induce mucosal, humoral and cellular immune responses. Salmonella can present antigen, stimulate specific humoral and cellular immune response against both Salmonella and heterologous antigen. So that Salmonella is considered as prospective vaccine vector. In this review, the strategy for constructions of attenuated Salmonella vector is described, including the attenuated Salmonella strains, high level expression of heterologous antigen, etc. At the end, it is prospected about the problems to be solved during the application of attenuated Salmonella vector. |
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| Keywords: | Attenuated Salmonella vector construction |
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