裸鼠、金黄地鼠、SD大鼠全血Casson值的检测与分析

目的 :了解裸鼠、金黄地鼠及 SD大鼠血液流变学参数正常值。方法 :采用锥板式粘度计对裸鼠、金黄地鼠、SD大鼠全血粘度进行同步检测 ,并采用线性回归的方法求出各组 Casson粘度 (CV)及 Casson(CY)屈服值。结果 :三种鼠高切粘度、红细胞压积、红细胞刚性指数检测值相近 ,裸鼠组检测值略高 ,但差异无统计学意义 (P>0 .0 5 ) ,低切粘度、红细胞聚集指数、血浆粘度差异显著性 (P<0 .0 1) ,大鼠值最高 ,统计学分析差异具显著意义。三种鼠 Casson粘度无明显差异 (P>0 .0 5 ) ,而 Casson屈服应力有显著差异 (P<0 .0 1)。结论 :结果提示三种动物红细胞变形能力基本相似 ,但涉及多种细胞外因素的红细胞聚集性则存在明显差异。

Detection and analysis of Cosson value on the whole blood of nude mice hamster and SD rats

Objective:To detect and analyze the normal hemorheological characteristics of nude mice,hamsters and Sprague-Dawley(SD)rats.Methods:The whole blood viscosity values of nude mice,hamsters and SD rats were tested simultaneously by means of the cone and plate viscometer,and Cosson Viscosity(CV)Cosson yield stress(CY)in the blood among them were calculated with unitary linear regression.Results:The whole blood viscosity at high shear rate,hemotocrit,and rigidity index of erythrocyte among 3 species of animals were similar,and there was a little higher in nude rate but no statistical difference;while there existed a significant difference in the values of whole blood viscosity at low shear rate,plasma viscosity and aggregation index of erythrocyte(P<0.01)among them.and SD rats exhibited the highest values.CV value showed no remarkable difference among 3 groups (P>0.05),whereas substantial difference was found in CY value(P<0.01).Conclusion:The erythrocyte deformability is nearly the same among 3 species of animals,but the erythrocyte aggregation involving many extracellular factors appears a noticeable difference.