Pedigree study of the heredity of copper-associated hepatitis in Dalmatians in Japan |
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| Authors: | Munekazu Nakaichi Toshie Iseri Hiro Horikirizono Harumichi Itoh Hiroshi Sunahara Yuki Nemoto Kazuhito Itamoto Kenji Tani |
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| Affiliation: | Department of Veterinary Radiology (Nakaichi, Iseri, Horikirizono), Department of Veterinary Small Animal Clinical Science (Itoh, Itamoto), Department of Veterinary Surgery (Sunahara, Nemoto, Tani), Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan |
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| Abstract: | The pedigrees of 3 Dalmatian dogs afflicted with copper-associated hepatitis were investigated to discover the mode of inheritance. A composite family pedigree showed that the 3 affected Dalmatians were related. None of the parents of the affected dogs showed clinical symptoms of liver disease, and the disease had no sex predisposition. The estimated segregation ratio was approximately 3:1 based on surviving littermates. These findings suggested that the copper-associated hepatitis in these Dalmatians was an autosomal recessive mode of inheritance. In addition, some male Dalmatians imported from abroad might have been involved in the occurrence of this disease in Japan. |
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