Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. |
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| Authors: | Fei He Linh H Mai Arlette Longeon Brent R Copp Nadège Loa?c Amandine Bescond Laurent Meijer Marie-Lise Bourguet-Kondracki |
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| Institution: | 1.Laboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d’Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France; E-Mails: (F.H.); (L.H.M.); (A.L.);2.School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; E-Mail: ;3.ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, France; E-Mails: (N.L.); (A.B.); (L.M.) |
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| Abstract: | Seven new adociaquinone derivatives, xestoadociaquinones A (1a), B (1b), 14-carboxy-xestoquinol sulfate (2) and xestoadociaminals A–D (3a, 3c, 4a, 4c), together with seven known compounds (5–11) were isolated from an Indonesian marine sponge Xestospongia sp. Their structures were elucidated by extensive 1D and 2D NMR and mass spectrometric data. All the compounds were evaluated for their potential inhibitory activity against eight different protein kinases involved in cell proliferation, cancer, diabetes and neurodegenerative disorders as well as for their antioxidant and antibacterial activities. |
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| Keywords: | kinase inhibitor adociaquinone xestoadociaquinone 14-carboxy-xestoquinol sulfate xestoadociaminal Xestospongia sp |
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