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Comparative Disposition Kinetics of Albendazole in Sheep Following Oral and Intraruminal Administration |
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| Authors: | Swarnkar C.P. Sanyal P.K. Singh D. Khan F.A. Bhagwan P.S.K. |
| Affiliation: | (1) 6Central Sheep and Wool Research Institute, Avikanagar, 304 501, Rajasthan, India;(2) Biotechnology Laboratory, National Dairy Development Board, nand, 388 001 Gujarat, India;(3) Central Sheep and Wool Research Institute, Avikanagar, 304 501 Rajasthan, India |
| Abstract: | The pharmacokinetics of albendazole was studied in sheep following single oral and intraruminal administration at nematocidal dose rates. The disposition curves of its metabolites indicated increased uptake of the drug in sheep following intraruminal as compared to oral dosing (p<0.05). The increased bioavailability of benzimidazole anthelmintics given by the intraruminal route could be exploited for optimizing the use of anthelmintic for sustained parasite control in small ruminants. |
| Keywords: | albendazole metabolites pharmacokinetics route of administration sheep |
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