| 新型吡唑酰胺类化合物的合成及其工艺研究 |
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| 引用本文： | 陈蔚燕,孟祥龙,许良忠.新型吡唑酰胺类化合物的合成及其工艺研究[J].农药科学与管理,2014(2):19-21. |
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| 作者姓名： | 陈蔚燕 孟祥龙 许良忠 |
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| 作者单位： | [1]青岛科技大学化学与分子工程学院农用化学品研究所,山东青岛266042; [2]青岛农业大学化学与药学院物理化学教研室,山东青岛266109 |
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| 摘 要： | 以2,3,5-三氯吡啶肼,康宽酸为起始原料反应合成新型吡唑酰胺类化合物,该化合物对小菜蛾的生物活性较高。通过正交试验进行优化,确定了其合成的最佳工艺方案:以乙腈作为溶剂,用碳酸钾作为缚酸剂,在吡啶肼和康宽酰氯的摩尔比为1∶3时,产物的产率最高达到97.4%。试验的结果表明:摩尔比和温度是反应的主要影响因素。
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| 关 键 词： | 康宽酸 吡啶肼 正交实验 |
Optimization of Synthesis Technology of Novel Pyrazole Amide by Orthogonal Test |
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| Institution: | Chert Weiyan, Meng Xianglong, Xu Liangzhong (Agrochemical Graduate School of Qingdao University of Science ＆ Technology, Chen Weiyan (College of Chemistry 266109, China) Qingdao 266042, China) and Pharmacy, Qingdao Agricultural University, Qingdao |
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| Abstract: | Novel pyrazole amide was synthesized from 2,3,5-Trichloropyridine and 3-bromo-1- （3-chloro-2-pyridiny 1）-lH-pyrazole-5-carboxylic acid as raw materials. This novel pyrazole amide has a high biological activity against asparagus caterpillar. The optimistic synthesis condi- tions were determined by orthogonal test as follows： npyridine： n3-bromo-l-（3-chloro-2- pyridiny 1）- 1H-pyrazole-5-carboxylic acid= 1：3, acetonitrile as solvent, potassium carbonate as acid-binding agent. The maximum yield can be reached as high as 97.4%. The result showed that the molar ratio and temperature were the main affecting factors to the reaction. |
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| Keywords: | 3 -bromo- 1 - （3 -chloro -2 -pyridiny 1 ） - 1H -pyrazole -5 -carboxylic acid 2 3 5 -Trichloropyridine Orthogonal test |
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