Sesquiterpene lactones from Sonchus arvensis L. and their antibacterial activity against Streptococcus mutans ATCC 25175 |
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| Authors: | Zhengxiang Xia Wei Qu Haiying Lu Juqin Fu Yanli Ren Jingyu Liang |
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| Institution: | 1. Department of Operative Dentistry and Endodontics, School of Stomatology, Fourth Military Medical University, Xi’an, China;2. Department of General Surgery, The 456th Hospital of PLA, Ji’nan City, Shandong, China;3. Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China;1. Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, India;2. Centre of Biomedical Research (CBMR), Sanjay Gandhi P ost-Graduate Institute of Medical Sciences Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India;3. Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, India;4. Department of Pharmacy, BITS-Pilani at Hyderabad Campus, Jawahar Nagar, Hyderabad 500 078, India;1. Key Laboratory for Space Bioscience and Space Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 YouyiXilu, Xi’an 710072, Shaanxi, PR China;2. Desert Plants & Ecological Civilization Research Center, Northwest University, 229 Tai Bai North road, Xi’an 710069, Shaanxi, PR China |
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| Abstract: | Two new sesquiterpene lactones, 1β-sulfate-5α, 6βH-eudesma-3-en-12, 6α-olide (1) and 1β-(p-hydroxyphenyl acetyl)-15-O-β-d-glucopyranosyl-5α, 6βH-eudesma-3-en-12, 6α-olide (2) were isolated from Sonchus arvensis L. (Asteraceae), together with eight known compounds. Their structures were elucidated through spectroscopic and chemical methods. They were evaluated for antibacterial activity. Among them, compounds 1 and 7 exhibited antibacterial activity against oral pathogen Streptococcus mutans ATCC 25175 with MIC values of 15.6 and 62.5 µg/ml, respectively. |
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