New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Lecanicillium fusisporum |
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| Authors: | Xinya Xu Yanhui Tan Chenghai Gao Kai Liu Zhenzhou Tang Chunju Lu Haiyan Li Xiaoyong Zhang Yonghong Liu |
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| Affiliation: | 1.Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China; (X.X.); (C.G.); (K.L.); (Z.T.); (C.L.); (H.L.);2.State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541004, China;3.College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China |
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| Abstract: | Seven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A–G (1–7), along with the known analogue cladosporiumin D (8), were obtained from the extract of the deep-sea-derived fungus Lecanicillium fusisporum GXIMD00542 within the family Clavipitacae. Their structures were elucidated by extensive spectroscopic data analysis, quantum chemistry calculations and chemical reaction. Compounds 1, 2, 5–7 exhibited moderate anti-inflammatory activity against NF-κB production using lipopolysaccharide (LPS) induced RAW264.7 cells with EC50 values range of 18.49–30.19 μM. |
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| Keywords: | tetramic acid derivatives deep-sea fungus clavipitacae Lecanicillium fusisporum anti-inflammatory activity |
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