颗粒粒径和粒谱对悬浮剂贮存物理稳定性影响研究

通过颗粒粒径和粒谱对悬浮剂贮存物理稳定性影响研究 ,明确了悬浮剂剂型加工中研磨时间与制剂悬浮颗粒粒径和粒谱分布的关系。结果表明 ,在选定了适当助剂、确定了加工工艺的条件下 ,通过调整研磨时间、降低悬浮颗粒粒径和粒谱分布 ,可以改善悬浮体系的物理稳定性。另外 ,由于研磨时间的延长、粒径变小所带来的悬浮体系粘度的增加 ,对制剂物理稳定性也是非常有利的。

Relationship between SC Stability withParticle Size and Size Distribution

The relationship between milling time of SC formulation processing with particle size and size distribution in suspension was described by studying the relationship of SC stability with particle size and size distribution. The result showed suspension physical stability could be improved by adjustment of milling time and decrease of particle size and size distribution, while suitable adjuvant and processing conditions were selected. Increase the viscosity of the suspension due to longer milling time and smaller particle size, would be more helpful to physical stability of the suspension.