| 副猪嗜血杆菌弱毒疫苗的研制 |
| |
| 引用本文： | 苏丹萍,王文豪,章胜,张丹琳,张显浩,陈瑞爱,贺东生.副猪嗜血杆菌弱毒疫苗的研制[J].中国畜牧兽医,2012,39(11):169-173. |
| |
| 作者姓名： | 苏丹萍 王文豪 章胜 张丹琳 张显浩 陈瑞爱 贺东生 |
| |
| 作者单位： | 1. 华南农业大学兽医学院,广东省人畜共患病重点实验室,广东广州 510642;2. 广东大华农动物保健品股份有限公司,广东新兴 527400 |
| |
| 摘 要： | 根据本教研室分离得到的副猪嗜血杆菌,选择毒力强、生长性能和毒力都稳定的菌株作为原始毒株。通过化学诱导剂诱导原始菌株发生突变,再经过毒力试验,挑选出毒力有明显减弱的菌株。安全性试验发现,这些减毒菌株具有较高的安全性,为弱毒疫苗的研制奠定基础。
|
| 关 键 词： | 副猪嗜血杆菌 化学诱导 减毒菌株 弱毒疫苗 |
| 收稿时间： | 2012-03-19 |
Development of Haemophilus parasuis Attenuated Strains |
| |
| SU Dan-ping
,
WANG Wen-hao
,
ZHANG Sheng
,
ZHANG Dan-lin
,
ZHANG Xian-hao
,
CHEN Rui-ai
,
HE Dong-sheng.Development of Haemophilus parasuis Attenuated Strains[J].China Animal Husbandry & Veterinary Medicine,2012,39(11):169-173. |
| |
| Authors: | SU Dan-ping WANG Wen-hao ZHANG Sheng ZHANG Dan-lin ZHANG Xian-hao CHEN Rui-ai HE Dong-sheng |
| |
| Institution: | 1. Guangdong Key Laboratory of Zoonosis, South China Agricultural University, Guangzhou 510642, China;2. Guangdong Dahuanong Animal Health Product Co., Ltd., Xinxing 527400, China |
| |
| Abstract: | According to Haemophilus parasuis which was isolated from the department,the strain of poison strong,stable growth and virulence stability was selected as the original strain. The original strain was induced to cause a mutation by chemical agents,then after toxicity test,significantly less virulent strains were selected. The safety trials found that these attenuated strains had a high security, and layed the foundation for the development of attenuated vaccine. |
| |
| Keywords: | Haemophilus parasuis chemically induced attenuated strains attenuated vaccine |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《中国畜牧兽医》浏览原始摘要信息 |
| 点击此处可从《中国畜牧兽医》下载免费的PDF全文 |
|
