自血穴位注射联合盐酸奥洛他定治疗慢性荨麻疹48例临床疗效及安全性评价

目的 研究自血穴位注射联合盐酸奥洛他定治疗慢性荨麻疹的临床疗效。方法 选取2014年6月至2015年6月，于湖南中医药大学第二附属医院皮肤科就诊并确诊、且自愿参与本研究的慢性荨麻疹患者96例，随机分为实验组（48例）和对照组（48例）。实验组患者采用口服盐酸奥洛他定+自血穴位注射方案治疗，对照组给予口服盐酸奥洛他定+穴位注射等容积生理盐水方案治疗，2次/周，连续12周。分析比较两组患者接受治疗后皮肤瘙痒程度、风团大小、风团数量等症状体征总积分变化、治疗有效率、复发率及不良反应发生情况。结果 实验组患者在症状体征积分改善、治疗有效率方面均优于对照组，差异有统计学意义（P<0.05）；两组复发率比较，差异有显著统计学意义（P<0.01）；两组患者不良反应发生率比较，差异无统计学意义（P>0.05）。结论 自血穴位注射联合盐酸奥洛他定治疗慢性荨麻疹，不仅可以改善临床症状和体征，提高治疗效果，而且能明显降低复发率，且安全性好，值得临床推广应用。

Clinical Efficacy and Safety of Autohemotherapy Combined with Olopatadine on 48 Cases of Chronic Urticaria

Objective To investigate the clinical efficacy and safety of autohemotherapy combined with olopatadine on inchronic urticaria.Methods The 96 patients who selected from the Second Afflicated Hosptial of Hunan Unversity of Chinese Medicine from June 2014 to June 2015 were randomly divided into the experimental group (48 cases) and the control gruop (48 cases).The experimental group was treated by oral administration of olopatadine and autohemotherapy.The control group was treated by oral olopatadine hydrochloride and equivalent volume saline injection.Both the experimental group and the control group were treated 2 times per week for 12 weeks.The extent of skin itching,the wheal size,the number of wheal and other symptoms and signs of the total score changes,the treatment efficiency,the recurrence rate and the adverse reaction incidence of the two groups before and after treatment were analysised and compared.Results The symptom score improvement and the efficiency of treatment in the the experimental group were superior to those in the control group (P<0.05),with statistical significance.The recurrence rate of the two groups was statistically significant (P<0.01).There were no difference in the incidence of adverse reaction between the experimental group and the control group (P>0.05).Conclusion The therapeutic method of autohemotherapy combined with olopatadine on chronic urticaria not only can improve the clinical symptoms,signs and clinical efficacy,but also reduce the recurrence rate.The therapeutic method is worthy of clinical popularization and application.