| 番鸭呼肠孤病毒弱毒疫苗在番鸭体内中和抗体消长规律的研究 |
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| 引用本文： | 程晓霞,陈少莺,林锋强,陈仕龙,朱小丽,王劭.番鸭呼肠孤病毒弱毒疫苗在番鸭体内中和抗体消长规律的研究[J].福建省农科院学报,2014(1):5-7. |
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| 作者姓名： | 程晓霞 陈少莺 林锋强 陈仕龙 朱小丽 王劭 |
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| 作者单位： | [1]福建省农业科学院畜牧兽医研究所,福建 福州 350013 [2]福建省畜禽疫病防治工程技术研究中心,福建 福州 350013 |
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| 基金项目： | 国家高技术研究发展计划（“863计划”）（2011AA10A209）;福建省科技计划重大专项（2006NZ0032）;福建省财政专项--福建省农业科学院创新团队建设项目（STIF-Y02）;福建省科技计划项目--省属公益类科研院所基本科研专项（2011R1025-7） |
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| 摘 要： | 为明确番鸭呼肠孤病毒弱毒疫苗在番鸭体内中和抗体消长规律，采用固定病毒稀释血清法，测定了经弱毒疫苗免疫后的雏番鸭不同时间其血清中和抗体效价。结果显示：疫苗注射1日龄雏番鸭，免疫后28 d部分鸭血清中出现抗体，35 d全部鸭血清中出现抗体；6个月抗体效价达高峰，有效免疫期在18个月以上。表明番鸭呼肠孤病毒弱毒疫苗诱导的中和抗体产生期较晚，但持续期长。
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| 关 键 词： | 番鸭呼肠孤病毒弱毒疫苗 中和抗体 产生期 持续期 |
The Study of Neutralization Antibody Evaluation against Muscovy Duck Reovirusis Alive Vaccine in Muscovy Ducklings |
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| Authors: | CHENG Xiao-xia CHEN Shao-ying LIN Feng-qiang CHEN Shi-long ZHU Xiao-li WANG Shao |
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| Institution: | 1. Institute of Animal Husbandry and Veterinary Medicine, Fijian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China 2. Fujian Animal Diseases Control Technology Development Center, Fuzhou, Fujian 350013, China) |
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| Abstract: | To determine antibody response in the serum of muscovy ducks immunized with muscovy duck reovirusis （MDRV） alive vaccine ,the fluctuation of antibody titers was detected in the serum by fixed virus-serum dilutions method .The results showed that some muscovy ducks turned positive on antibody against MDRV after vaccination in 28th day ,while all of them appeared to be MDRV-antibody positive within 35 days ;the peak titer of the antibody showed at the 6th month after vaccination ,and the period of effective immunization could last over 18 months .The results told that there was a long delay between MDRV vaccination and antibody origin ,while the duration of antibody production was relatively long ,which provided scientific basis for immune procedure development . |
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| Keywords: | Muscovy duck reovirusis alive vaccine neutralization antibody production period duration period |
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