| 黄芪、板蓝根对猪细小病毒体外抑制作用研究 |
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| 引用本文： | 王学斌,魏战勇,崔保安,惠永华,徐端红.黄芪、板蓝根对猪细小病毒体外抑制作用研究[J].中国预防兽医学报,2006,28(6):715-719. |
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| 作者姓名： | 王学斌 魏战勇 崔保安 惠永华 徐端红 |
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| 作者单位： | 河南农业大学,牧医工程学院,河南,郑州,450002 |
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| 摘 要： | 为研究中草药黄芪、板蓝根作为抗病毒药物的效果及初步机理，利用细胞病变（CPE）抑制实验测定黄芪、板蓝根单独使用及1：1联合使用在PK-15单层细胞上对猪细小病毒（PPV）的抑制作用。结果表明：板蓝根单独使用时体外对PPV有明显的抑制作用，其对PPV的最小直接杀灭浓度为0．62mg／mL，最小阻断浓度为0．31mg／mL；而黄芪单独使用时对PPV无明显的抑制作用。板蓝根、黄芪1：1联合使用时对PPV的抑制作用显著增强，其对PPV的最小直接杀灭浓度提高为0．31mg／mL，最小阻断浓度提高为0．075mg／mL。
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| 关 键 词： | 黄芪 板蓝根 猪细小病毒 |
| 文章编号： | 1008-0589(2006)-06-0715-05 |
| 收稿时间： | 2005-12-18 |
| 修稿时间： | 2005年12月18 |
The in vitro antiviral activity of Radix Astragali and Radix Isatidis to porcine parvovirus |
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| WANG Xue-bin,WEI Zhan-yong,CUI Bao-an,HUI Yong-hua,XU Duan-hong.The in vitro antiviral activity of Radix Astragali and Radix Isatidis to porcine parvovirus[J].Chinese Journal of Preventive Veterinary Medicine,2006,28(6):715-719. |
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| Authors: | WANG Xue-bin WEI Zhan-yong CUI Bao-an HUI Yong-hua XU Duan-hong |
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| Institution: | Engineering College of Animal and Veterinary Science, Henan Agricultural University, Zhengzhou 450002, China |
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| Abstract: | To study the anti-PPV(porcine Parvovirus)activity and mechanism of Radix Isatidis and Radix Astragali,Radix Isatidis and Radix Astragali were used separately and then mixed to challenge the PPV(porcine Parvovirus)cultured in PK-15 cell based on the inhibition to cytopathogenic effect(CPE).Minimal inhibitory concentration(MIC)and minimal stop concentration(MSC)had been determined directly and indirectly.The results showed that the anti-PPV cutivities of 1:1 mixture of Radix Astragadi and Radix Isatidis were significantly higher than that of Radix lsatidis,their MIC is 0.31 mg/mL, and their MSC is 0.075 mg/mL. |
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| Keywords: | Radix Astragali Radix Isatidis PPV |
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