| 家蝇幼虫抗菌肽MDL-2干扰细菌功能的初步研究 |
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| 引用本文： | 宫霞,乐国伟.家蝇幼虫抗菌肽MDL-2干扰细菌功能的初步研究[J].河南农业大学学报,2011,45(4). |
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| 作者姓名： | 宫霞 乐国伟 |
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| 作者单位： | 1. 上海商学院食品学院,上海,200235
2. 江南大学食品学院,江苏无锡,214036 |
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| 基金项目： | 上海市教委科研创新项目(09YZ470); 中央级科研院所基础性专项资金工作项目重点项目(2001DEA—20022) |
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| 摘 要： | 研究了家蝇幼虫抗菌肽MDL-2对细菌细胞壁的溶解作用、细胞膜渗透性和代谢的影响.抗菌肽MDL-2在抗菌过程中首先与细菌的细胞壁相互作用,使其破裂.菌肽对革兰氏阴性细菌大肠杆菌的细胞壁的作用有浓度依赖性,而对革兰氏阳性细菌金黄色葡萄球菌,MDL-2在较低的浓度时即具有破坏细胞壁的作用;抗菌肽MDL-2与金黄色葡萄球菌的细胞膜作用曲线呈现典型的S型,有较强的协同效应,并随着作用时间的延长细胞的渗透性增强;抗菌肽对细菌的代谢功能有较强的干扰作用,阻碍菌体的生命活动,加速菌体死亡.
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| 关 键 词： | 家蝇幼虫 抗菌肽 渗透性 β-半乳糖苷酶 代谢 |
A temporary Study on antimicrobial peptide MDL-2 from Musca domestica Larvae interfering metabolism of bacteria |
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| GONG Xia,LE Guo-wei.A temporary Study on antimicrobial peptide MDL-2 from Musca domestica Larvae interfering metabolism of bacteria[J].Journal of Henan Agricultural University,2011,45(4). |
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| Authors: | GONG Xia LE Guo-wei |
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| Institution: | GONG Xia1,LE Guo-wei2(1.Department of Food Science,Shanghai Business School,Shanghai 200235,China,2.School of Food Science,Jiangnan University,Wuxi 214036,China) |
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| Abstract: | Effects of antimicrobial peptide MDL-2 from Musca domestica Larvae on dissolution and permeability and metabolism of bacteria were studied in this paper.The cell wall of bacteria was ruptured by interaction antimicrobial peptide MDL-2 with bacteria,gram-negative bacteria,E.coli had concentration-dependency when antibacterial peptide MDL-2 assembled to certain concentration on cell outer membrane;The cell wall of gram-positive bacteria,S.aureus was fallen apart in lower concentration of MDL-2.The S-type grap... |
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