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Bioactive 7-Oxabicyclic[6.3.0]lactam and 12-Membered Macrolides from a Gorgonian-Derived Cladosporium sp. Fungus |
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| Authors: | Fei Cao Qin Yang Chang-Lun Shao Chui-Jian Kong Juan-Juan Zheng Yun-Feng Liu Chang-Yun Wang |
| Institution: | 1Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; E-Mails: (F.C.); (C.-L.S.); (C.-J.K.); (J.-J.Z.); (Y.-F.L.);2Chinese Center for Chirality, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, and College of Pharmacy Sciences, Hebei University, Baoding 071002, China; E-Mail: |
| Abstract: | One new bicyclic lactam, cladosporilactam A (1), and six known 12-membered macrolides (2–7) were isolated from a gorgonian-derived Cladosporium sp. fungus collected from the South China Sea. Their complete structural assignments were elucidated by comprehensive spectroscopic investigation. Quantum chemistry calculations were used in support of the structural determination of 1. The absolute configuration of 1 was determined by calculation of its optical rotation. Cladosporilactam A (1) was the first example of 7-oxabicyclic6.3.0]lactam obtained from a natural source. Compound 1 exhibited promising cytotoxic activity against cervical cancer HeLa cell line with an IC50 value of 0.76 μM. |
| Keywords: | gorgonian-derived fungus Cladosporium sp bicyclic lactam 12-membered macrolides cytotoxic activity |