| 微量元素锰对小鼠骨髓细胞微核率的影响 |
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| 引用本文： | 彭小武,吴颖慧,张乐,王颖.微量元素锰对小鼠骨髓细胞微核率的影响[J].新疆农业科学,2004,41(6):416-418. |
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| 作者姓名： | 彭小武 吴颖慧 张乐 王颖 |
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| 作者单位： | 新疆农业大学药学院,新疆乌鲁木齐,830000 |
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| 摘 要： | 微核实验是短期检测遗传毒性化学物的最常用的方法.以小鼠为实验材料,以MN的化合物(二氯化锰)作为受试物,进行了骨髓细胞微核率的检测,推断出二氯化锰是一种染色体诱变剂,对人及动物具有潜在的致突变和遗传损伤作用.通过对小鼠不同染毒次数、不同采样时间微核数的观察,表明多次染毒并于末次染毒后12 h取样,微核观察计数的效果好.
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| 关 键 词： | 锰 小鼠 微核 |
| 文章编号： | 1001-4330(2004)06-0416-03 |
| 收稿时间： | 2004-06-25 |
| 修稿时间： | 2004年7月2日 |
The Effect of Microelement on Micronucleus Cell Rate of Rat's Marrow Cell |
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| PENG Xiao-wu,WU Ying-hui,ZHANG Le,WANG Ying.The Effect of Microelement on Micronucleus Cell Rate of Rat's Marrow Cell[J].Xinjiang Agricultural Sciences,2004,41(6):416-418. |
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| Authors: | PENG Xiao-wu WU Ying-hui ZHANG Le WANG Ying |
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| Abstract: | Micronucleus test is often used to examine genotoxicity compound in a short time.Through injecting Manganese compound (MnCl_2) into rat's abdominal cavity and observing Micronucleus cell in polychromatic erythrocyte(MNPCE),we deduce MnCL_2 may be a chromosome mutagen,which has potential mutagenicity and genetic damage.In addition,comparing with the results of different injecting toxic times and different sampling time,we know that on condition that rats are injected toxin 5 times and marrow are sampled in 12 hours after the last injection,the effect of observing MNPCE is better than the others. |
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| Keywords: | manganese rat micronucleus |
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