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A Possible treatment strategy and clinical factors to estimate the treatment response in Bebesia gibsoni infection
Authors:Suzuki Koretoki  Wakabayashi Haruna  Takahashi Masashi  Fukushima Kenjiro  Yabuki Akira  Endo Yasuyuki
Affiliation:Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshivma University, Korimoto, Kagoshima, Japan.
Abstract:The effectiveness of combination therapy using clindamycin, metronidazole and doxycycline against canine babesiosis, and the usefulness of platelet count and the plasma C-reactive protein (CRP) concentration as an estimation factor for treatment, were evaluated in four dogs experimentally infected with Babesia gibsoni. The combination therapy successfully eliminated B. gibsoni in peripheral blood in 3 of 4 dogs, however the remaining dog showed obvious uncontrolled relapse after a temporary recovery. In addition, it was shown that CRP levels decreased in an inverse relationship to the recovery of packed cell volume and therefore CRP levels could be used as an optional clinical marker to estimate the response to treatment.
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