A型流感病毒跨种传播和致病性相关蛋白研究进展

A型流感病毒是重要的人和动物病原体,每年都会在人群中引发季节性流感流行,偶尔还会引发全球流感大流行,对公共卫生安全构成严重威胁.研究发现,A型流感病毒的跨种传播与该病毒的多个蛋白有关,其中血凝素是该病毒宿主范围的主要限制因素,但聚合酶蛋白和非结构蛋白1(NS1)的作用也不容忽视.A型流感病毒通过不断地适应各类宿主和长期...

Progress on Proteins Related to Cross-species Transmission and Pathogenicity of Influenza A Viruses

Influenza A viruses are important human and animal pathogens.They cause seasonal epidemics and occasional global pandemics,so they pose a serious public health threat.Multiple proteins of influenza A viruses are implicated in the cross-species transmission of these viruses,of which the virus hemagglutinin is the major limiting factor in host range,however,the polymerase protein and the non-structural protein 1 also play an important role.In each year,there are a various of new strains with unknown pathogenicity by constantly adapting to various hosts and long-term evolution,the pathogenicity of influenza A viruses are mainly affected by certain specific amino acid substitutions of polymerase protein,hemagglutinin and non-structural protein 1.In this paper,the research progress on the molecular mechanism of cross-species transmission and pathogenicity of influenza A viruses were reviewed.