化学趋化因子与家畜疾病

在人类和小鼠，已经发现并确定了50余种化学趋化因子和20余种化学趋化因子受体，而在兽医领域中，已经发现并确定的化学趋化因子及其受体数量较少。化学趋化因子及其受体不仅在机体T、B淋巴细胞发育、成熟、归巢以及免疫反应中起着重要作用，还在炎症反应中与炎症细胞浸润到组织损伤部位过程中起着关键性的作用。化学趋化因子及其受体还与许多家畜疾病的发生、发展密切相关。作者还介绍了动物病毒模仿编码的化学趋化因子或化学趋化因子结合蛋白及可能的生物学功能并讨论了化学趋化因子及其受体研究在兽医领域的发展前景。

Chemokines,Chemokine Receptors and Domestic Animal Diseases

Chemokines and their receptors play a pivotal role in the development and maturation of immune cells and immune response, and also associated with the development of many diseases. There are more than 50 kinds of chemokines and 20 kinds of their receptors that have been identified from human or mice, but only a few are known in domestic veterinary species. The chemokines and their receptors are crucial during inflammatory responses for a timely recruitment of specific leukocyte subpopulations to sites of tissue damage. However, chemokines and their receptors are also important in angiogenesis and angiostasis, T, B cell development and maturation, T, B cell -homing. On the other hand, many domestic animal diseases are associated with overexpression of chemokines and their receptors. Furthermore, some chemokine/chemokine receptors like molecules or chemokine binding proteins encoded by a number of veterinary viral pathogens and the putative biological functions are introduced. Further research on the promising area in the appliance of chemokines/chemokine receptors is discussed.