| 低毒力新城疫抗原抗体复合物疫苗研究 |
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| 引用本文： | 章振华,姜北宇,李林,毛娅卿,李永清,张建伟,景小冬,郑小兰.低毒力新城疫抗原抗体复合物疫苗研究[J].动物医学进展,2008,29(11). |
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| 作者姓名： | 章振华 姜北宇 李林 毛娅卿 李永清 张建伟 景小冬 郑小兰 |
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| 作者单位： | 1. 北京市农林科学院畜牧兽医研究所,北京,100097
2. 中国兽医药品监察所,北京,100081 |
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| 摘 要： | 用低毒力新城疫病毒LaSota株作为复合物疫苗抗原，与新城疫特异性中和抗体混匀配制了不同比例的8种复合物疫苗，用1日龄SPF雏鸡进行免疫效果试验。试验l组～8组分别免疫复合物疫苗1～8，试验9组免疫常规新城疫活疫苗，试验10组为空白对照组。免疫后3周采血测定HI抗体效价，同时用新城疫强毒北京株F48E9攻击。试验l组～10组HI抗体效价分别为2^3.6、2^3.1、2^2.3、2^4.85、2^4.85、2^5.0、2^5.0、2^4.5、2^5.1、2^2.14。攻毒后1组～10组鸡的死亡率分别为30％、50％、90％、10％、0％、0％、0％、0％、09，6、100％。结果表明，低毒力新城疫病毒LaSota株与特异性抗体制备的复合物疫苗，可以减轻疫苗的毒副作用，提高疫苗的安全性，其免疫效果比常规活苗好。
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| 关 键 词： | 新城疫病毒 La Sota毒株 抗原抗体复合物疫苗 免疫效果 |
Study on Antigen-antibody Complex Vaccine of Low Virulent Newcastle Disease |
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| ZHANG Zhen-hua,JIANG Bei-yu,LI Lin,MAO Ya-qing,LI Yong-qing,ZHANG Jian-wei,JING Xiao-dong,ZHENG Xiao-nan.Study on Antigen-antibody Complex Vaccine of Low Virulent Newcastle Disease[J].Progress In Veterinary Medicine,2008,29(11). |
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| Authors: | ZHANG Zhen-hua JIANG Bei-yu LI Lin MAO Ya-qing LI Yong-qing ZHANG Jian-wei JING Xiao-dong ZHENG Xiao-nan |
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| Institution: | 1.Institute of Animal Husbandry and Veterinary Medicine;Beijing Academy of Agriculture and Forestry Sciences;Beijing;100097;China;2.China Institute of Veterinary Drug Supervision;100081;China |
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| Abstract: | Eight kind of complex vaccines were prepared from a low virulence NDV La Sota strain and the specific antibodies against NDV in different ratios,the immune effect tests of lyophilized vaccines were carried out with one-day-old SPF chicks.Chicks in group 1-8 were vaccinated with complex vaccines 1-8 respectively,chicks in group 9 were vaccinated with La Sota live vaccine,and chicks in group 10 were not vaccinated with any vaccine.Blood samples were taken three weeks post-immunization,and levels of anti-NDV a... |
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| Keywords: | Newcastle disease viru La Sota strain antigen-antibody complex vaccine immune effect |
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