三种多糖对小鼠免疫功能的影响

为探讨黄芪多糖、酵母胞壁多糖和虫草菌丝体多糖对动物免疫功能的影响,本试验分为对照组和黄芪多糖、酵母胞壁多糖、虫草菌丝体多糖,3种多糖等量复配4个试验组。每组选用昆明种小鼠40只,对照组小鼠每只灌胃1mL生理盐水,黄芪多糖、酵母胞壁多糖、虫草菌丝体多糖和3种多糖等量复配组小鼠每只灌胃量为140mg多糖/kg体重,每隔10d取样1次,分别检测增重率、免疫器官指数、血细胞数和外周血IgG含量。结果表明,黄芪多糖组、酵母胞壁多糖组和虫草菌丝体多糖组均可显著提高小鼠增重率、免疫器官指数、血细胞数目及外周血IgG含量(P<0.05),复合多糖组则与单多糖组相比差异显著(P<0.05)。说明3种多糖组及其混合多糖组均能提高小鼠免疫力,且最好的为混合多糖组。

Effects of Three Kinds of Polysaccharides on Immune Function of Mice

For studying the immune function of the astragalus polysaccharides,yeast cell wall polysaccharides,mycelial polysaccharides of Cordyceps,this test was divided into a control group,APS group,the yeast cell wall polysaccharide group,Cordyceps mycelial polysaccharide group,the group of combination of three kinds of polysaccharides.200 Kunming mice were randomly divided into five groups of 40 mice each.The mice in control group was given 1ml normal saline,the mice in experimental groups were given the corresponding polysaccharide 140 mg/kg.Weight gain rate,the index of immune organs,blood cell count and IgG,were measured every 10 d.The results showed that yeast cell wall polysaccharides,APS and mycelial polysaccharides of Cordyceps can significantly increase weight gain rate,the index of immune organs and blood cell count and IgG(P<0.05).Compared with single polysaccharides,the compound polysaccharides has significant difference(P<0.05).The single polysaccharide and the compound polysaccharides can improve immune function in mice,and the best is the compound polysaccharides.