新杀螨活性化合物螺甲丁酯(AC-118)的合成及应用

现阶段杀螨剂的大量使用,导致害螨的抗药性逐年增加,因此有必要开发新型、高效的杀螨剂。参照螺甲螨酯的合成方法,合成了新杀螨活性化合物螺甲丁酯(AC-118)。分别测试了AC-118对朱砂叶螨螨卵和雌成螨的毒力,并考察了其对山楂叶螨的田间防效。结果表明:AC-118的结构经~1H NMR确认。初步活性试验显示:其对朱砂叶螨螨卵和雌成螨的LC_(50)分别为2.4 mg/L和6.7 mg/L;田间施药后14天,2000倍和3000倍剂量下,24%AC-118 SC对山楂叶螨的防效分别为96.1%和93.0%,24%AC-118 ME的防效分别为97.2%和94.6%;3000倍剂量下,24%螺甲螨酯SC的防效为93.9%。AC-118与螺甲螨酯的防效相当。相对于传统杀螨剂来说,AC-118具有活性高、速效性好和持效期长的优点,可对其进行进一步的开发研究。

Synthesis and Application of New Acaricidal Compound 3-(2,4,6-trimethyl-phenyl)-2-oxo-1-oxaspiro[4.4]non-3-en-4-yl butane-1-sulfonate

With frequent and extensive use of acaricides, mites have increased resistance to acaricides. It is necessary to develop a new type and highly effective acaricide. A new acaricidal compound 3-(2,4,6-trimethyl-phenyl)-2-oxo-1-oxaspiro4.4]non-3-en-4-yl butane-1-sulfonate (AC-118) was synthesized with reference to the synthetic method of spiromesifen. The toxicity of AC-118 against eggs and female adults of Tetranychus cinnabarinus was tested by leaf-dipping method and slide-dip method, respectively. The field control efficacy against Tetranychus vinnensis was also evaluated. The structure of AC-118 was confirmed by 1H NMR. The preliminary bioassay results showed that LC50 of AC-118 against eggs and female adults of Tetranychus cinnabarinus were 2.4 mg/L and 6.7 mg/L, respectively. 14 d after spraying in field, at the dosage of 2000 and 3000 times, the field control efficacy of 24%AC-118 SC against Tetranychus vinnensis was 96.1%and 93.0%, respectively. The field control efficacy of 24%AC-118 ME against Tetranychus vinnensis was 97.2% and 94.6%, respectively. At 3000 times, the field control efficacy of 24%spiromesifen SC was 93.9%. The control effect of AC-118 on Tetranychus cinnabarinus was equivalent to that of spiromesifen. Compared with the traditional acaricides, AC-118 had the advantages of high bioactivity, rapid availability and long efficacy duration, and could be further developed and studied.