A new antifungal coumarin from Clausena excavata |
| |
Authors: | Kumar Ramashish Saha Aniruddha Saha Dipanwita |
| |
Affiliation: | a Department of Biotechnology, North Bengal University, Dist.-Darjeeling, Siliguri-734013, Indiab Department of Botany, North Bengal University, Dist.-Darjeeling, Siliguri-734013, India |
| |
Abstract: | A new γ-lactone coumarin, named as excavarin-A, showing antifungal activity was isolated from the leaves of Clausena excavata by bioassay guided fractionation method. The structure was elucidated by spectroscopic data analysis and identified as 7((2E)-4(4,5-dihydro-3-methylene-2-oxo-5-furanyl)-3-methylbut-2-enyloxy) coumarin. Minimum inhibitory concentration (MIC) was determined against fifteen fungal strains pathogenic against plants and human. The least MIC was recorded against the human pathogen, Candida tropicalis and the plant pathogens Rhizoctonia solani and Sclerotinia sclerotiorum. Antifungal activities against the human pathogens, Aspergillus fumigatus and Mucor circinelloides and plant pathogens, Colletotrichum gloeosporioides, Lasiodiplodia theobromae, Fusarium oxysporum and Rhizopus stolonifer were stronger than that of the standard antimicrobials. |
| |
Keywords: | Clausena excavata Rutaceae Coumarin Antifungal activity |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|