普洱茶提取物对自发性高血压大鼠降压研究

采用自发高血压大鼠（SHR）进行普洱茶提取物降压功效的研究。给予普洱茶提取物0.25、0.5、1.0、2.0g/kg灌胃4周,观察动物的血压、心率、体重变化。结果显示,以普洱茶提取物1.0g/kg和2.0g/kg灌胃4周,对动物的平均动脉压、收缩压和舒张压均有降低作用,与模型组间存在显著差异（P<0.01）。普洱茶提取物0.25g/kg和0.5g/kg组动物血压较模型组没有显著性改变。普洱茶提取物2.0g/kg可提高动物的心率,有抑制其体重增长的趋势;其他剂量组动物的心率及体重增长均无显著变化。研究表明,普洱茶提取物对自发高血压大鼠具有降压作用,且具有剂量依赖性。

Anti-hypertension Effect of Pu-erh Tea Extract on Spontaneous Hypertension Rats

To explore the anti-hypertension effect of Pu-erh tea extract on SHR.Pu-erh tea extract was administered to SHR for 4 weeks with 0.25,0.5,1.0,2.0 g/kg doses.The blood pressure and heart rate of animals were measured once every week,and the body weight was also measured weekly in the research.Results showed that the mean blood pressure,systolic pressure and diastolic pressure of spontaneous hypertension rats were significantly reduced in the treatment with 1.0 g/kg and 2.0 g/kg Pu-erh tea extract,compared with that of model group(P<0.01).The body weight of animal in 2.0 g/kg Pu-erh tea extract group was lower when compared with model group,but the heart rate of this group was higher than model group.The heart rate and the increase of body weight of tested animal in the other dose group were non-significantly difference.Conclusions: The Pu-erh tea extract shows dose-dependent antihypertensive effect in spontaneous hypertension rats.