Cytomegalovirus recruitment of cellular kinases to dissolve the nuclear lamina |
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Authors: | Muranyi Walter Haas Jürgen Wagner Markus Krohne Georg Koszinowski Ulrich H |
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Institution: | Genzentrum and Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universit?t München, 80336 München, Germany. |
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Abstract: | The passage of large-sized herpesviral capsids through the nuclear lamina and the inner nuclear membrane to leave the nucleus requires a dissolution of the nuclear lamina. Here, we report on the functions of M50/p35, a beta-herpesviral protein of murine cytomegalovirus. M50/p35 inserts into the inner nuclear membrane and is aggregated by a second viral protein, M53/p38, to form the capsid docking site. M50/p35 recruits the cellular protein kinase C for phosphorylation and dissolution of the nuclear lamina, suggesting that herpesviruses target a critical element of nuclear architecture. |
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