New coumarin glycosides from the leaves of Diospyros crassiflora (Hiern) |
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| Authors: | Carine Mvot Akak Céline Mbazoa Djama Augustin Ephrem Nkengfack Peng-Fei Tu Lian-Di Lei |
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| Institution: | 1. Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box: 812, Yaounde, Cameroon;2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China |
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| Abstract: | Two new 5-methylcoumarin glycosides named diosfeboside A (1) and B (2) and five known compounds namely kaempferol 3-O-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranoside (3), ursolic acid (4), betulinic acid (5), stigmasterol (6) and stigmasterol 3-O-β-d-glucopyranoside (7) were isolated from the leaves of Diospyros crassiflora (Hiern). Their structures were established through interpretation of 1 and 2D NMR, mass spectra analysis and comparison with reported data. In vitro cytotoxic activity of the new compounds against human carcinoma cell lines (HL-60, Bel-7402, BGC-823, and KB) was evaluated and no cytotoxicity was observed for each of them. |
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| Keywords: | Diospyros crassiflora Ebenaceae Coumarin glycosides Diosfeboside A Diosfeboside B Cytotoxic activity |
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