The essential oil of Eucalyptus tereticornis, and its constituents α- and β-pinene,potentiate acetylcholine-induced contractions in isolated rat trachea |
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Authors: | Francisco JB Lima Teresinha S Brito Walter BS Freire Roberta C Costa Maria I Linhares Francisca CF Sousa Saad Lahlou José H Leal-Cardoso Armênio A Santos Pedro JC Magalhães |
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Institution: | 1. Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil;2. Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará, Brazil |
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Abstract: | The effects of the essential oil of Eucalyptus tereticornis (EOET), especially the effects of its constituents α- and β-pinene, were studied on rat trachea in vitro. In tracheal rings, EOET, α- or β-pinene potentiated the contractions induced by acetylcholine (ACh). Contractions induced by K+ (60 mM) were also potentiated by α- and β-pinene, but were reduced by EOET. Our findings show that EOET has myorelaxant effects on rat airways, but potentiates ACh-induced contractions. Monoterpenes α- and β-pinene are involved in its potentiating actions, but are not responsible for its myorelaxant effects. A putative inhibition of the acetylcholinesterase enzyme is involved. |
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Keywords: | Monoterpenes Airways Acetylcholinesterase Eucalyptus |
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