Affiliation: | a Institute of Molecular Biology and Medicine, University of Scranton, Scranton, PA 18510, USA b Integrated Genomics, Inc., 2201 W. Campbell Park Drive, Chicago, IL 60612, USA c Department of Veterinary Science, LSU AgCenter, Baton Rouge, LA 70803, USA |
Abstract: | The genome of Brucella melitensis strain 16M was sequenced and contained 3,294,931 bp distributed over two circular chromosomes. Chromosome I was composed of 2,117,144 bp and chromosome II has 1,177,787 bp. A total of 3198 ORFs were predicted. The origins of replication of the chromosomes are similar to each other and to those of other -proteobacteria. Housekeeping genes such as those that encode for DNA replication, protein synthesis, core metabolism, and cell-wall biosynthesis were found on both chromosomes. Genes encoding adhesins, invasins, and hemolysins were also identified. |