Effects of dexamethasone on acute lung injury by inhibiting renin-angiotensin system in rats |
| |
Authors: | ZHANG Yong LOU Dong-mei LI Hong-yan JIN De-nan GAO Jing-zhensi YU Zhen-xiang |
| |
Institution: | 1.Department of Pathophysiology, Basic Medical College, Jilin University,4Department of Respiratory, The First Hospital of Jilin University, Changchun 130021, China;2.Central Hospital of Changchun, Changchun 130051, China;3.Department of Pharmacology, Osaka Medical University, Japan. E-mail: yuzhenxiang2005@sina.com |
| |
Abstract: | AIM:To explore the relationship between renin-angiotensin system (RAS) and acute lung injury (ALI) in rats, and the effect of dexamethasone (DEX) on RAS was observed.METHODS: The rat model of ALI was induced by hemorrhagic shock and LPS administered intraperitoneally. The changes of MAP and the effects of DEX on MAP were observed. The mRNA expressions of ACE, AGT, AT1 and AT2 in lung tissue were assayed by RT-PCR. The changes of Ang I and Ang II in the serum and the effects of DEX on them were observed.RESULTS: The increasing of MAP was statistically obvious. MAP in hemorrhagic shock+LPS (HL) group recovered more slowly than that in HL+DEX(HLD) group. ACE, AGT, AT1 and AT2 mRNA expressions in HL group were increased, and higher than those in HLD group. The change of Ang II in serum in HL group was obviously higher than that in HLD group, while that of Ang I was not obvious.CONCLUSION:ALI activates RAS in rat lung, and promotes the production of Ang II then aggravates the injury of lung through increasing the expression of ACE and AGT. DEX decreases expression of Ang II. |
| |
Keywords: | |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|