麒麟菜膳食纤维的降血脂功能

以3种麒麟菜(Eucheuma spp.)膳食纤维为研究对象,给予SD大鼠10%膳食纤维的高脂饲料进行6周的动物实验,分别于0周、3周、6周末眼底采血、收集实验末期3d粪便,通过分析血清总脂(TL)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、粪便胆固醇(FC)、粪便胆汁酸(FBA)和计算动脉硬化指数(AI),研究了麒麟菜膳食纤维降低血脂的功能活性。结果显示:实验至3周、6周末,喂饲高脂饲料的阳性对照组和3个麒麟菜膳食纤维实验组的大鼠血清TL、TC、TG、LDL-C水平较阴性对照组显著升高(P<0.05),3种膳食纤维组TL、TC、TG、LDL-C水平显著低于阳性对照组(P<0.05),HDL-C水平显著低于阴性对照组而高于阳性对照组(P<0.05)。6周末,3种膳食纤维粪便胆固醇FC和粪便胆汁酸FBA含量显著高于阴性和阳性对照组(P<0.05)。结果表明,本实验高脂饲料可成功形成高脂动物模型,3种膳食纤维具有显著抑制TL、TC、TG、LDL-C水平升高,促使HDL-C水平升高和粪便胆固醇、粪便胆汁酸排泄的功能。因此,麒麟菜膳食纤维显示出降低血脂的效果,将有可能在预防高血脂症等疾病方面具有应用价值。

Functional effect of dietary fiber from Eucheuma on reducing serum lipids

It was reported that the dietary fiber(DF)had preventive effects on coronary heart diseases.There abundant dietary fi ber in seaweed of Eucheuma,especially soluble dietary fi ber.In this research,the functional effect of three kinds of dietary fiber from Eucheuma,which was soluble dietary fiber(SDF),insoluble dietary fi ber(IDF)and total dietary fi ber(TDF),on reducing serum lipids was studied by giving SDrats high lipid diets with 10% of DF supplementation.During the test,serum samples from eye socket were analyzed for TL,TG, LDL-C and HDL-C at 0 week,3 rd week and 6 th week,respectively,and the atherosclerosis index (AI) was calculated.In the end of the experiment,faecal matter of the last 3 days was collected continuously and analyzed for the faecal cholesterol and faecal bile acid content.The results showed that:at the end of 3 rd week and 6 th week,the serum TL,TC,TG and LDL-C levels of positive control and DF group were signif icantly higher than those of the negative control(P<0.05),and the TL,TC,TG and LDL-C levels of DF groups were signif icantly lower than positive control(P<0.05).However the HDL-C level of DF test group was significantly lower than those of the negative control(P<0.05),and higher than those of the positive control(P<0.05).At the end of the experiment,the DF groups had significantly higher FC and FBA levels compared with negative control and positive control(P<0.05).The results above demonstrate that the test diets with high lipid can form the hyperlipidemia-model rat.The increase of TL,TC,TG and LDL-C levels in rat serum could be restrained by DF from Eucheuma.In addition,DF from Eucheuma had a function of triggering higher HDL-C level and accelerating the excretion of FBA and FC.Therefore,DF from Eucheuma has an effect on reducing lipids and may be applied in preventing hyperlipidaemic diseases.