| 吡喹酮和硝硫氰醚对日本血吸虫体内5-HT含量的影响 |
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| 引用本文： | 余祖功,包鸿俊.吡喹酮和硝硫氰醚对日本血吸虫体内5-HT含量的影响[J].动物医学进展,2002,23(5):82-83. |
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| 作者姓名： | 余祖功 包鸿俊 |
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| 作者单位： | 南京农业大学动物医学院,江苏南京,210095 |
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| 基金项目： | 国家自然科学基金项目 (39170 5 78) |
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| 摘 要： | 本文研究了吡喹酮和硝硫氰醚与日本血吸虫拟似神经递质 5-羟色胺间的关系。以吡喹酮 ( 5× 1 0 - 7mol/ L和 5× 1 0 - 8mol/ L )、硝硫氰醚 ( 1 0 - 4mol/ L和 1 0 - 5mol/ L )分别培养日本血吸虫成虫 4h和 8h ,反相离子对高效液相法测定其体内 5-HT的含量变化。结果显示 :吡喹酮和硝硫氰醚对日本血吸虫体内 5-HT等含量的影响与对照相比均无显著性差异。表明二者抗虫作用似不通过影响虫体 5-HT的生物合成和降解。
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| 关 键 词： | 吡喹酮 硝硫氰醚 日本血吸虫 5－HT含量 |
| 文章编号： | 1007-5038(2002)05-0082-02 |
| 修稿时间： | 2002年4月23日 |
Effects of Praziquantel and Nitroscanate on 5-HT Levels in S.japonicum |
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| YU Zu-gong,BAO Hong-jun.Effects of Praziquantel and Nitroscanate on 5-HT Levels in S.japonicum[J].Progress In Veterinary Medicine,2002,23(5):82-83. |
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| Authors: | YU Zu-gong BAO Hong-jun |
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| Abstract: | Effects of Praziquantel and Nitroscanate on 5-HT levels in S.japonicum were studied. Following 4h,8h in vitro incubations, the levels of 5-HT and related compounds were investigated by high performance liquid chromatography with UV detector. The results showed that two antischistosomal drugs didn't change levels of 5-HT and related compounds in S.japonicum statistically. This could be explained that their mechanisms may not involve in synthesis and degradation of 5-Ht in S.japonicum. |
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| Keywords: | Schistosoma japonicum 5-Hydroxytryptamine(5-HT) praziquantel nitroscanate |
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