氟氯苯菊酯在犬体内的药动学初步研究

研究自制1%氟氯苯菊酯浇泼剂在健康家犬体内的药代动力学特征。选用6条健康犬,以2mg/kg单剂量沿背中线浇泼,采用反相高效液相色谱法(RP-HPLC)测定犬血浆中氟氯苯菊酯浓度,用3P97药动软件处理药时数据,计算药代动力学参数。氟氯苯菊酯的药时数据符合一级吸收二室开放模型,主要药动学参数为:T1/2α为(3.622±1.079)h,T1/2β为(22.654±0.417)h,T1/2Ka为(1.684±0.240)h,AUC为(47.385±1.709)μg.mL-1.h,Tpeak为(4.165±0.187)h,Cmax为(1.902±0.064)μg/mL,Lagtime为(0.489±0.002)h。健康家犬单次给予氟氯苯菊酯浇泼剂后,吸收、消除均缓慢,药物在动物体内作用时间较长。

Preliminary studies on pharmacokinetics of flumethrin in dogs

Pharmacokinetics of flumethrin pour - on preparation （ 1% ） was studied in healthy dogs. Flumethrin pour- on preparation was dermal administrated in a dose of 2 mg/kg ·bw in 6 healthy dogs and the plasma concentration of flumethrin was detected by RP - HPLC. The concentration - time date were analyzed with 3P97 computer program. The pharmacokinetics characteristics was fit to two -compartment model with first order absorption rate. The main pharmaeokinetics parameters were as follows ： T1/2α was （ 3. 622 ± 1. 079 ） h, T1/2β was （22.654 ± 0.417） h, T1/2Ka was （ 1. 684 ± 0. 240） h,AUC was （47. 385 ± 1. 709） μg ·mL^-1 ·h, Tpeak was （4. 165 ± 0.187 ） h, Cmax was （ 1. 902 ± 0. 064 ） μg/mL, Lag - time was （0. 489 ± 0.002 ） h. It was concluded that flumethrin both been absorbed and eliminated slowly and had a long persistence time.