首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Transdisciplinary unifying implications of circadian findings in the 1950s
Authors:Franz Halberg  Germaine Cornélissen  George Katinas  Elena V Syutkina  Robert B Sothern  Rina Zaslavskaya  Francine Halberg  Yoshihiko Watanabe  Othild Schwartzkopff  Kuniaki Otsuka  Roberto Tarquini  Perfetto Frederico  Jarmila Siggelova
Institution:Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA. halbe001@umn.edu
Abstract:Afew puzzles relating to a small fraction of my endeavors in the 1950s are summarized herein, with answers to a few questions of the Editor-in-Chief, to suggest that the rules of variability in time complement the rules of genetics as a biological variability in space. I advocate to replace truisms such as a relative constancy or homeostasis, that have served bioscience very well for very long. They were never intended, however, to lower a curtain of ignorance over everyday physiology. In raising these curtains, we unveil a range of dynamics, resolvable in the data collection and as-one-goes analysis by computers built into smaller and smaller devices, for a continued self-surveillance of the normal and for an individualized detection of the abnormal. The current medical art based on spotchecks interpreted by reference to a time-unqualified normal range can become a science of time series with tests relating to the individual in inferential statistical terms. This is already doable for the case of blood pressure, but eventually should become possible for many other variables interpreted today only based on the quicksand of clinical trials on groups. These ignore individual differences and hence the individual's needs. Chronomics (mapping time structures) with the major aim of quantifying normalcy by dynamic reference values for detecting earliest risk elevation, also yields the dividend of allowing molecular biology to focus on the normal as well as on the grossly abnormal.
Keywords:
本文献已被 PubMed SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号