Discovery and structure-activity relationship studies of novel tetrahydro-β-carboline derivatives as apoptosis initiators for treating bacterial infections |
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作者姓名: | Shanshan Su Hongwu Liu Junrong Zhang Puying Qi Yue Ding Ling Zhang Linli Yang Liwei Liu Xiang Zhou Song Yang |
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基金项目: | the supports from National Natural Science Foundation of China (21877021, 32160661, and 32202359);;the Program of Introducing Talents of Discipline to Universities of China (D20023, 111 Program); |
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摘 要: | Developing and excavating new agrochemicals with highly active and safe is an important tactic for protecting crop health and food safety.In this paper, to discover the new bactericide candidates, we designed, prepared a new type of1,2,3,4-tetrahydro-β-carboline(THC)derivatives and evaluated the in vitro and in vivo bioactivities against the Xanthomonas oryzae pv.oryzae(Xoo),Xanthomonas axonopodis pv.citri(Xac),and Pseudomonas syringae pv.actinidiae (Psa).The in vitro bioassay results exhibited ...
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