| 固醇转运蛋白SCP-2研究进展 |
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| 引用本文： | 陈苗,艾雪,金松恒,江敏利,郑炳松.固醇转运蛋白SCP-2研究进展[J].浙江林学院学报,2009,26(5):735-741. |
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| 作者姓名： | 陈苗 艾雪 金松恒 江敏利 郑炳松 |
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| 作者单位： | 1. 浙江林学院,浙江省现代森林培育技术重点实验室,浙江,临安,311300
2. 浙江省温岭市箬横镇人民政府,浙江,温岭,317507 |
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| 基金项目： | 浙江省自然科学基金资助项目，浙江省留学回国基金资助项目，浙江林学院科学研究发展基金和浙江省森林培育重中之重学科开放基金资助项目 |
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| 摘 要： | 固醇转运蛋白（SCP-2,也称非特异性脂类转移蛋白）是一类碱性小分子蛋白质,存在于过氧化物酶体中,在体外可以增强质膜间胆固醇和脂类的运输,广泛存在于细菌、古细菌和真核生物中。大量的研究表明,它与多种物质的代谢过程有关,但由于它复杂的结构和功能,其具体作用机制目前仍未被明确阐述。为此,作者着重以真核生物SCP-2家族为例,介绍了SCP-2结构域的进化、结构与功能近年来的研究进展,并对SCP-2基因家族及SCP-2蛋白应用前景作了论述。
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| 关 键 词： | 生物化学 固醇转运蛋白 分子结构 功能 |
A review of research on sterol carrier protein-2 |
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| CHEN Miao,AI Xue,JIN Song-heng,JIANG Min-li,ZHENG Bing-song.A review of research on sterol carrier protein-2[J].Journal of Zhejiang Forestry College,2009,26(5):735-741. |
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| Authors: | CHEN Miao AI Xue JIN Song-heng JIANG Min-li ZHENG Bing-song |
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| Institution: | CHEN Miao, AI Xue, JIN Song-heng, JIANG Min-li, ZHENG Bing-song ( 1. The Key Laboratory for Modem Silvicultural Technology of Zhejiang Province, Zhejiang Forestry College, Lin＇ an 311300, Zhejiang, China; 2. The People＇s Government of Ruoheng Township, Wenling 317507, Zhejiang, China) |
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| Abstract: | Sterol carrier protein-2 （SCP-2,also known as the non-specific lipid transfer protein） is an in-tracellular,small,basic protein domain that in vitro enhances the transfer of lipids and sterol between membranes. It is widely existed in bacteria,archaea,and eukaryotes. The roles of SCP-2 remain unclear owing to its complicated structure and function although there are suggestions that SCP-2 involves in catalyzing metabolism of plentiful matters. The purpose of this review is to summarize our current knowledge about evolution, structure and function of the eukaryotic SCP-2 gene family and discuss potential functions of SCP-2 in vivo or vitro as studied in large numbers of experiments in recent years. Furthermore, the SCP- 2 gene and the application of SCP-2 are discussed. |
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| Keywords: | biochemistry sterol carrier protein-2（SCP-2） molecular structure function |
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