| Wnt信号通路及其在动物生长发育过程中的作用 |
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| 引用本文： | 韩琳,冯新港.Wnt信号通路及其在动物生长发育过程中的作用[J].中国兽医寄生虫病,2008,16(3):47-52. |
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| 作者姓名： | 韩琳 冯新港 |
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| 作者单位： | 1. 上海师范大学生命与环境科学学院,上海,200234;中国农业科学院上海兽医研究所,上海,200232
2. 中国农业科学院上海兽医研究所,上海,200232 |
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| 摘 要： | Wnt途径是重要的细胞信号转导途径，该途径参与了从胚胎到成体的一系列控制胚胎早期的发育、决定细胞分化、细胞增殖及生长的调控，异常表达或激活该途径会导致各种疾病甚至肿瘤发生。本文重点阐述了Wnt信号通路在胚胎发育、细胞分化及其在肿瘤发生过程中的作用，同时揭示深入研究Wnt信号通路，设计出阻断Wnt通路的物质，可为将来肿瘤的治疗开辟一条新的途径。
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| 关 键 词： | Wnt信号通路 胚胎发育 细胞分化 肿瘤发生 |
| 文章编号： | 1005-0868(2008)03-0047-06 |
| 修稿时间： | 2008年3月4日 |
WNT SIGNALING PATHWAY AND ITS ROLE DURING ANIMALS GROWTH AND DEVELOPMENT |
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| HAN Lin,FENG Xin-gang.WNT SIGNALING PATHWAY AND ITS ROLE DURING ANIMALS GROWTH AND DEVELOPMENT[J].Chinese Journal of Veterinary Parasitology,2008,16(3):47-52. |
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| Authors: | HAN Lin FENG Xin-gang |
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| Institution: | HAN Lin, FENG Xin-gang ( 1. Life and Environment College of Shanghai Normal University, Shanghai 200234, China ; 2. Shanghai Institute of Veterinary Science, CAAS ,Shanghai 200232, China) |
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| Abstract: | Wnt signaling plays an important role in many processes of life, regulating early embryonic development, cell differentiation, cell proliferation and growth. Abnormal expression or activation of Wnt signaling pathway will result in many diseases and tumors. In the review we focus on the roles of Wnt signaling in embryonic development, cell differentiation and tumorigenesis. In addition, it deserves further research on the components of Wnt signaling pathway to contrive valuable targets for potential anticancer agents. |
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| Keywords: | Wnt signaling pathway embryonic development cell differentiation tumorigenesis |
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