Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein from inactivation caused by physiological concentrations of hypochlorite |
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| Authors: | Alejandro Gugliucci Deborah H Markowicz Bastos |
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| Institution: | 1. Glycation, Oxidation and Disease Laboratory, Touro University-California, Vallejo, CA, USA;2. Nutrition Department, School of Public Health, São Paulo University, Brazil |
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| Abstract: | We hypothesized that chlorogenic acids, the main phenolics in coffee, many fruits and Ilex paraguariensis extracts, protect paraoxonase 1 activity in HDL from inactivation by chlorination at concentrations of HOCl (50 μM) and chlorogenic acid (2–10 μM) compatible with those found in humans. |
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| Keywords: | ABCAI ATP binding cassette apolipoprotein AI 5-CQ acid 5 caffeoylquinic acid CG chlorogenic MPO Myeloperoxidase PON-1 paraoxonase-1 |
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