Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae) |
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| Authors: | Federica Menichini Rosa TundisMonica R. Loizzo Marco BonesiMariangela Marrelli Giancarlo A. StattiFrancesco Menichini Filomena Conforti |
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| Affiliation: | Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Italy |
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| Abstract: | Ethanolic extract from the fruits of Pimpinella anisoides, an aromatic plant and a spice, exhibited activity against AChE and BChE, with IC50 values of 227.5 and 362.1 μg/ml, respectively. The most abundant constituents of the extract were trans-anethole, (+)-limonene and (+)-sabinene. trans-Anethole exhibited the highest activity against AChE and BChE with IC50 values of 134.7 and 209.6 μg/ml, respectively. The bicyclic monoterpene (+)-sabinene exhibited a promising activity against AChE (IC50 of 176.5 μg/ml) and BChE (IC50 of 218.6 μg/ml). |
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| Keywords: | Aromatic plant Cholinesterase inhibition activity Pimpinella anisoides Terpenes Apiaceae |
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