Three new sesquiterpenes from Tithonia diversifolia and their anti-hyperglycemic activity |
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Authors: | Guijun Zhao Xia Li Wansheng Chen Zhongxin Xi Lianna Sun |
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Institution: | 1. School of Pharmacy, Second Military Medical University, Guohe Road 325#, Shanghai 200433, People''s Republic of China;2. Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Fengyang Road 415#, Shanghai 200003, People''s Republic of China |
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Abstract: | Three new germacrane sesquiterpenes (1), (2), (3), along with eleven known sesquiterpenes, namely, tirotundin-3-O-methyl ether (4), deacetylvguiestin (5), 1β-hydroxydiversifolin-3-O-methyl ether (6), tagitinin C (7), 1β-hydroxytirotundin-3-O-methyl ether (8), 1β-hydroxytirotundin-1,3-O-dimethyl ether (9), tagitinin F-3-O-methyl ether (10), tagitinin F (11), tagitinin A (12), 3β-acetoxy-4α-hydroxyeduesm-11(13)-en-12-oic acid (13) and ilicic acid (14) were isolated from the aerial parts of Tithonia diversifolia. Their structures were established by spectroscopic analysis, while the relative configuration of compound 1 was confirmed by X-ray diffraction analysis. In addition, compounds 1–14 were evaluated in vitro for their anti-hyperglycemic activity by glucose uptake in 3T3-L1 adipocytes. It was found that 10 μg/mL 1, 3, 6 and 8 could significantly increase glucose uptake without significant toxic effects. |
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Keywords: | Tithonia diversifolia Germacrane sesquiterpene 3T3-L1 adipocytes |
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