遗传毒性致癌物风险评估的新技术

为调查市售贝类产品中氯霉素的残留状况并对该情况进行暴露评估，2015—2017年采集贝类样品共300个，采用液质法进行检测。将结果运用@risk软件进行蒙特卡罗模拟分析，通过计算膳食摄入量和人群估计暴露量，对所得结果进行暴露边界比(margin of exposure，MOE)评价。结果显示，2015年有33个样品有检出，人群平均暴露的MOE值为15 361，按照加拿大卫生部的评价标准，属于中危害水平。高暴露人群的MOE值为5 208，属于中危害水平。2016年有3个样品有检出，人群平均暴露的MOE值为103 627，属于中危害水平。高暴露人群的MOE值为34 722，属于中危害水平。2017年未检出氯霉素，属于无危害水平。

Thermal degradation of chloramphenicol in model solutions,spiked tissues and incurred samples

In order to investigate the chloramphenicol residues in commercially available shellfish and to assess their exposure, we collected 300 shellfish samples which were determined by LC-MS/MS and analyzed by @risk software using Monte Carlo method. The daily intake and estimated dietary exposure were simulated, and the margins of exposure were calculated. The results show that 33 samples were determined to have chloramphenicol residues in 2015. The MOE value of the general population was 15 361, presenting a medium risk (according to the evaluation criteria of the Canadian Ministry of Health). The MOE value of the high exposure population was 5 208, also presenting a medium risk. In 2016, three samples were determined to have chloramphenicol residues. The MOE value of the general population was 10 3627, presenting a medium risk. The MOE value of the high exposure population was 34 722, presenting a medium risk. In 2017, no samples were determined to have chloramphenicol residues, presenting no risk.