| 副猪嗜血杆菌血清5型岳阳株对昆明小鼠淋巴器官损伤的研究 |
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| 引用本文： | 邓治邦,潘荞,袁安文,王乃东,薛立群.副猪嗜血杆菌血清5型岳阳株对昆明小鼠淋巴器官损伤的研究[J].中国预防兽医学报,2011,33(1). |
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| 作者姓名： | 邓治邦 潘荞 袁安文 王乃东 薛立群 |
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| 作者单位： | 湖南农业大学,动物医学学院,湖南,长沙,410128 |
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| 基金项目： | 湖南省科技重大专项资助项目 |
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| 摘 要： | 为探讨副猪嗜血杆菌(HPS)对免疫器官的损伤,本实验将HPS血清5型岳阳株及其茵体裂解物分别接种昆明小鼠,结果显示:HPS血清5型岳阳株及其菌体裂解物,均能够引起昆明小鼠颈淋巴结细胞凋亡和坏死.组织病理学检测可见脾脏红髓扩张、白髓萎缩、淋巴细胞衰减;胸腺病变较轻,皮质部局灶性淋巴细胞坏死和散在性细胞凋亡.此外,免疫器官损伤与剂量相关,随菌量的增大病变更为明显.HPS血清5型岳阳株及其菌体裂解物对昆明小鼠淋巴器官有明显的损伤作用.
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| 关 键 词： | 副猪嗜血杆菌岳阳株 淋巴器官损伤 昆明小鼠 |
Lesion in lymphoid organs of Kunming mice experimentally inoculated with a Yueyang strain of Haemophilus parasuis serotype 5 |
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| DENG Zhi-bang,PAN Qiao,YUAN An-wen,WANG Nai-dong,XUE Li-qun.Lesion in lymphoid organs of Kunming mice experimentally inoculated with a Yueyang strain of Haemophilus parasuis serotype 5[J].Chinese Journal of Preventive Veterinary Medicine,2011,33(1). |
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| Authors: | DENG Zhi-bang PAN Qiao YUAN An-wen WANG Nai-dong XUE Li-qun |
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| Institution: | DENG Zhi-bang,PAN Qiao,YUAN An-wen,WANG Nai-dong,XUE Li-qun*(College of Veterinary Medicine,Hunan Agricultural University,Changsha 410128,China) |
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| Abstract: | In order to explore the lesions of immune organs caused by Haemophilus parasuis infection,mice were experimentally inoculated with a Yueyang strain of H.parasuis serotype 5 and tissue lesions in the immune organs were examined.Cytonecrosis and apoptosis of lymphocytes in germinal center of cervical lymph node,expanding red pulp with white pulp atrophy,lymphocyte depletion of spleen,cytonecrosis of lymphocyte with scattered cells apoptosis in cortex of thymus could be observed following infection by H.parasu... |
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| Keywords: | Yueyang strain of Haemophilus parasuis lesion of lymphoid organs Kunming mice |
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