Delayed-type hypersensitivity in sheep induced by synthetic peptides of bovine leukemia virus encapsulated in mannan-coated liposome |
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Authors: | Okada Kosuke Sonoda Kai Koyama Masato Yin Shanai Ikeda Manabu Goryo Masanobu Chen Sau Leok Kabeya Hidenori Ohishi Kazue Onuma Misao |
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Institution: | Department of Veterinary Pathology, Faculty of Agriculture, Iwate University, Ueda, Morioka, Japan. |
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Abstract: | Four sheep were immunized with synthesized peptides, derived from bovine leukemia virus (BLV) envelope glycoprotein, encapsulated in mannan coated liposomes as adjuvant. On the seventh day after the immunization, the sheep were intradermally challenged with BLV antigen, or synthesized peptides. The areas challenged with antigen were increased skin thickness and biopsied sequentially for immunohistological examinations. Strong delayed-type hypersensitivity was induced in sheep immunized and challenged with peptides encapsulated in mannan-coated liposomes. The major phenotype of the infiltrating lymphocytes was CD5(+). The ratio of CD4(+) to CD8(+) cells was about 1:1. |
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