| 烟碱对大鼠心电图的影响 |
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| 引用本文： | 刘鼎阔,籍永录,丁增伟,裴志花,张延林,焦石. 烟碱对大鼠心电图的影响[J]. 动物医学进展, 2008, 29(3): 50-53 |
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| 作者姓名： | 刘鼎阔 籍永录 丁增伟 裴志花 张延林 焦石 |
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| 作者单位： | 吉林农业大学动物科技学院,吉林长春,130118;吉林省通化市公园管理处,吉林通化,134001;吉林农业大学农学院,吉林长春,130118 |
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| 摘 要： | 烟碱对心率的作用具有阶段性,初期引起心率短暂性减弱,紧接着发生瞬时增加。为进一步确定烟碱对大鼠心脏的作用,对描记烟碱作用后大鼠心电图进行分析,发现烟碱能引起大鼠心电图显示较长的QT间期,增加了PR间期及T波面积,与肾上腺素或去甲肾上腺素引起的QT间期延长相似,且能被M受体阻断剂阿托品所阻断,说明烟碱能够诱导局部释放乙酰胆碱或者作用于部分副交感神经控制的毒蕈碱受体。
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| 关 键 词： | 烟碱 心电图 QT间期 去甲肾上腺素 |
| 文章编号： | 1007-5038(2008)03-0050-04 |
| 修稿时间： | 2007-11-30 |
The Influence of Nicotine on Rat ECG |
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| LIU Ding-kuo,JI Yong-lu,DING Zeng-wei,PEI Zhi-hua,ZHANG Yan-lin,JIA Shi. The Influence of Nicotine on Rat ECG[J]. Progress In Veterinary Medicine, 2008, 29(3): 50-53 |
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| Authors: | LIU Ding-kuo JI Yong-lu DING Zeng-wei PEI Zhi-hua ZHANG Yan-lin JIA Shi |
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| Abstract: | The nicotine has a stage function to the heart rate, first causing a brief decrease followed by a transient increase. In order to verify nicotine effect to heart of rat, analyzing the (electrograph) ECG at the nicotine to rat, it was discovered that nicotine can cause a longer QT interval and increase the PR interval and T-wave area,with the function likeness of adrenaline or noradrenalin, was blocked furthermore by M-subunit antagonist atropine. Based on these results, it was demonstrated that nicotine can induce to release acetylcholine locally or act on muscarinic cholinoreceptor controlled by parasympathetic nerve. |
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| Keywords: | Nicotine Electrograph(ECG) QT interval Norepinephrine |
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