引起仔猪当前腹泻难治的病菌分析及药敏试验

采用实验室方法分离鉴定了引起猪腹泻的细菌,并对分离菌进行超广谱β-内酰胺酶（ESBLs）检测和对24种抗菌药、5种复方药的敏感性测定。结果显示,分离细菌为大肠杆菌、沙门氏菌、志贺氏菌、奇异变形杆菌,有的且产生ESBLs。药敏试验结果表明该菌对兽医临床中常用的β-内酰胺类抗生素、氟喹诺酮类、氯霉素类、氨基糖苷类等均产生耐药;对粘杆菌素、亚胺培南、美罗培南敏感,β-内酰胺类药物与酶抑制剂联用能使药物对细菌的最低抑菌浓度（M ICs）降低,因此复方β-内酰胺类药物是治疗猪腹泻的有效措施之一。

Analyzing and Drug Sensitive Test of Hard-to-cure Pathogenic Bacteria Causing Young Swine Diarrhea

Bacteria which caused young swine diarrhea were isolated and identified through laboratory means, the extended spectrum 13 -lactamase （ ESBLs）, 24 species antibacterial and 5 pharmacopoeia compound phar- maceutical sensitivity were determinated. Results showed that the separated bacterium were Escherichia coli which produced ESBLs, salmonella, Shigella, Proteus mirabilis. Drugs sensitivity test results showed that the bacterium produced drug resistance to many usual veterinary clinical drugs, such as 13- lactam antibiotics, quinolones, ehloramphenicoles, aminoglycoside and so on. The bacteria was sensitive to polymycin, imipenem, meropenem, 13-lactam drugs and enzyme inhibitor combination could decrease the minimum inhibitory con- centration （M IC）, Therefore one of effective treating measures for salpingitis were using 13 -lactam drug and en- zyme inhibitor combination.